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AM-2201 is a full agonist for cannabinoid receptors. Affinities are: with a Ki of 1.0 nM at CB1 and 2.6 nM at CB2 The 4-methyl functional analog MAM-2201 probably has similar affinities.] AM-2201 has an EC50 of 38 nM for human CB1 receptors, and 58 nM for human CB2 receptorsAM-2201 produces bradycardia and hypothermia in rats at doses of 0.3-3 mg/kg, comparable to the potency of JWH-018 in rats, suggesting potent cannabinoid-like activity.